rs281875215
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Rare, highly penetrant, gain-of-function, dominantly acting mutations within the human caspase recruitment domain family, member 14 (CARD14) gene lead to the development of PS and psoriatic arthritis (PSA) (a familial p.G117S and de-novo p.E138A alteration).
|
31323190 |
2019 |
rs281875214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rare, highly penetrant, gain-of-function, dominantly acting mutations within the human caspase recruitment domain family, member 14 (CARD14) gene lead to the development of PS and psoriatic arthritis (PSA) (a familial p.G117S and de-novo p.E138A alteration).
|
31323190 |
2019 |
rs11652075
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.
|
27706581 |
2016 |
rs11652075
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF therapies among patients with psoriasis.
|
26854129 |
2016 |
rs281875215
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In contrast with wild-type CARD14, CARD14(E138A) and CARD14(G117S) psoriasis mutants interacted constitutively with BCL10 and MALT1, and triggered BCL10- and MALT1-dependent activation of NF-κB in keratinocytes.
|
27071417 |
2016 |
rs281875214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Inhibition of MALT1 with mepazine reduced CARD14(E138A)-induced expression of specific psoriasis-associated transcripts in keratinocytes.
|
27071417 |
2016 |
rs11652075
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We confirmed the association between SNP rs11652075 at the CARD14 gene and Psor.
|
23905699 |
2013 |
rs281875215
|
|
|
0.030 |
GeneticVariation |
BEFREE |
One family exhibiting suggestive evidence for linkage to 17q25 (PSORS2) was identified and all affected members harboured a p.Gly117Ser mutation in CARD14 (caspase recruitment domain family, member 14), recently reported to lead to psoriasis in a large family from the U.S.A.
|
23013406 |
2013 |
rs11652075
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
rs11652075
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
rs11652075
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Over 20 CARD14 polymorphisms were also genotyped, and meta-analysis revealed an association between psoriasis and rs11652075 (c.2458C>T [p.Arg820Trp]; p value = 2.1 × 10(-6)).
|
22521419 |
2012 |